Mass General Brigham

Site: The General Hospital Corporation

Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

Job Summary

For specific inquiries, please email aestanton@mgh.harvard.edu with the subject header "Research Position Inquiry: Research Fellow in Delivery to the Brain." Applicants should send a cover letter, CV, and contact information for three professional references. Accompanying letters of recommendation are encouraged but not strictly required.

The Stanton Lab in the Center for Genomics Medicine (CGM) and Department of Neurology at Harvard Medical School and Massachusetts General Hospital is seeking a highly motivated and skilled scientist to be the driver of our effort to develop new approaches for enhanced delivery to the brain, towards the delivery of genetic medicines and realization of precision medicine approaches. The scientist will build on and further develop close collaborations with world-leading experts within Harvard Medical School and Massachusetts General Hospital and technology of the Stanton Lab (www.stantonlab.info).

Core areas of focus will include the development of advanced preclinical screening tools, generation of vectors and formulation of nanoparticles and other molecules, evaluation in animal models and in vitro systems. The candidate will join a multidisciplinary and highly collaborative research environment that includes neuroscientists, geneticists, bioengineers, computational biologists, and physician-scientists at the CGM and Department of Neurology, as well as at other leading academic institutions and biopharmaceutical companies.

Qualifications

Ph.D. in Chemical Engineering, Bioengineering, Pharmaceutical Science, Neuroscience, Biology, or related field with deep expertise in drug transport techniques

• Develop novel in vitro and in vivo assays for evaluating functionality, targeting efficiency and potency of novel delivery modalities
• Be interested in realizing a precision medicine approach to neurological disorders and highly practical, actionable, and translational research
• Strong skills in rodent handling, dosing (IC, IV, etc.) and necropsy (preferred)
• Strong skills in tissue culture and bioreactor design (preferred)
• Strong skills in lipid nanoparticle (LNP) formulation, characterization, and analysis techniques (preferred)
• Strong skills in pre-formulation work such as solubility, stability, and excipient compatibility testing (preferred)
• Knowledge of experimental design
• Statistical and quantitative analysis skills
• Basic bioinformatics skills
• Self-motivated and highly dedicated
• Effective organizational and prioritization skills
• Effective oral, written, and interpersonal communication skills
• Ability to work both independently as well as collaboratively in a multidisciplinary environment
• Strong skills in mathematical modeling of molecular diffusion in multi-phase systems and determining primary rate limiting physical and chemical properties of model and molecules of interest (preferred)
• Strong skills in integrating output of laboratory and mathematical simulations to provide drug delivery guidelines for molecular transport across multi-phase systems as a function of molecular properties (preferred)

For specific inquiries, please email aestanton@mgh.harvard.edu with the subject header "Research Position Inquiry: Research Fellow in Delivery to the Brain." Applicants should send a cover letter, CV, and contact information for three professional references. Accompanying letters of recommendation are encouraged but not strictly required.

Additional Job Details (if applicable)

Remote Type

Onsite

Work Location

185 Cambridge Street

Scheduled Weekly Hours

40

Employee Type

Regular

Work Shift

Day (United States of America)

EEO Statement:

The General Hospital Corporation is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran’s Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642.

Mass General Brigham Competency Framework

At Mass General Brigham, our competency framework defines what effective leadership “looks like” by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.