School of Medicine Established in 1930, Duke University School of Medicine is the youngest of the nation's top medical schools. Ranked sixth among medical schools in the nation, the School takes pride in being an inclusive community of outstanding learners, investigators, clinicians, and staff where interdisciplinary collaboration is embraced and great ideas accelerate translation of fundamental scientific discoveries to improve human health locally and around the globe. Composed of more than 2,500 faculty physicians and researchers, more than 1,300 students, and more than 6,000 staff, the Duke University School of Medicine along with the Duke University School of Nursing, Duke University Health System and the Private Diagnostic Clinic (PDC) comprise Duke Health. a world-class academic medical center. The Health System encompasses Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Primary Care, Duke Home and Hospice, Duke Health and Wellness, and multiple affiliations.
Postdoctoral Position to identify genetic regulatory mechanisms of HKDC1 on gestational hyperglycemia
Duke University has an immediate opening for a postdoctoral fellow to research the causes of adverse pregnancy outcomes such as gestational diabetes. The research will focus on identifying new genetic and molecular mechanisms using leading edge high-throughput methods such as CRISPR/Cas9-based genome and epigenome editing. The research would expand on an existing body of work to understand a newly identified hexokinase gene, HKDC1, in human and mouse; and would also investigate additional genes and genetic loci that are much less well studied to date. The position is funded through an NIDDK research grant that investigates the impact of liver HKDC1 and its association with gestational metabolism. The project is led by PI Dr. Tim Reddy and this position would report directly to Dr. Reddy.
The successful applicants will lead experimental design on CRISPR systems, generate and analyze data, and lead manuscript development. We are particularly interested in candidates with expertise in genome and epigenome editing; CRISPR-based disease modeling; protein engineering; and/or high-throughput genetics, genomics, or epigenetics studies. In addition to Dr. Reddy, the candidate will work with a team of faculty, postdoctoral associates, graduate and undergraduate students conducting research and training on human gene regulation.
The position will be based in Durham NC, and will involve travel to related scientific meetings.
Applicants must have completed their doctoral degree, and have documented experience in one or more areas described above. The ideal candidate will also have a demonstrated track record of scientific productivity, for example via published manuscripts and/or fellowship funding; experience analyzing data from high-throughput biological experiments; and is excited to work in a highly collaborative and multi-disciplinary research environment.
Duke University is a comprehensive research institution that includes a remarkably wide range of academic departments and programs (www.duke.edu) and is recognized as one of the premier research institutions in the United States. Duke is uniquely positioned to provide excellent opportunities for collaboration with colleagues across a variety of disciplines.
Minimum Degree Requirements: Ph.D. or equivalent doctorate (e.g. Sc.D., M.D., D.V.M.). Should be used for post-doctoral fellows if the candidate has completed all of the requirements for a degree, but the degree has not been formally conferred; the candidate may present evidence of completion of the degree requirements, together with a statement documenting the date on which the degree is to be conferred.
Other Credential/Experiential Requirements:
Duke is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation, or veteran status. Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas—an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.
Essential Physical Job Functions: Certain jobs at Duke University and Duke University Health System may include essential job functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.
Duke is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation, or veteran status.
Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas—an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.
Essential Physical Job Functions: Certain jobs at Duke University and Duke University Health System may include essentialjob functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.
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