Job Description
At Cincinnati Children’s, we come to work with one goal: to make children’s health better. We believe in a holistic team approach, both in caring for patients and their families, and in advancing science and discovery. We strive to do better and find energy and inspiration in our shared purpose. If you want to be the best you can be, you can do it at Cincinnati Children’s.
Cincinnati Children's is:
- Recognized by U.S. News & World Report as a top 10 best children's hospitals in the nation for more than 15 years
- Second Among All Children's Hospitals for National Institutes of Health (NIH) Funding
- Recognized as one of America’s Best Large Employers (2025) , America’s Best Employers for New Grads (2024)
- One of the nation's America’s Most Innovative Companies as noted by Fortune
- Consistently certified as great place to work
- A Leading Disability Employer as noted by the National Organization on Disability
- Magnet® designated for the fourth consecutive time by the American Nurses Credentialing Center (ANCC)
We are seeking a highly motivated and detail-oriented Variant Scientist to join our clinical molecular and genomic pathology services (MGPS) laboratory in the Division of Pathology in Cincinnati Children’s Hospital. It is a team of ~25 staff members, including dedicated clinical bioinformatics team, variant scientist and 2 full time molecular pathology faculty.
The successful candidate will be responsible for the curation, interpretation, and clinical annotation of somatic and/or germline variants derived from next-generation sequencing (NGS) assays for pediatric and young adult tumors. This role plays a critical part in the production of high-quality, accurate, and clinically relevant genomic reports to guide cancer diagnosis, prognosis, and therapeutic decision-making.
Hours: M-F 8am-4:30 (flexible) - hybrid flexibility (2-3 days WFH) is possible after onsite training is completed.
Key Responsibilities
- Perform detailed review and clinical annotation of genomic alterations (SNVs, indels, CNVs, LOH, fusions) detected using NGS, in accordance with professional society guidelines.
- Evaluate the clinical significance of variants using established public databases and peer-reviewed literature.
- Collaborate with molecular pathologists, bioinformaticians, and technologists to support accurate variant calling and interpretation.
- Contribute to the development and maintenance of internal variant classification databases and knowledgebases.
- Prepare high-quality written interpretations for integration into clinical molecular pathology reports.
- Participate in the validation and implementation of new molecular assays and informatics tools.
- Maintain current knowledge of molecular oncology, targeted therapies, and biomarker guidelines.
- Ensure compliance with laboratory quality control procedures, regulatory requirements, and data security standards.
MINIMUM QUALIFICATIONS
- Bachelor of Science Degree in Clinical Laboratory Science OR equivalent combination of education and experience
- 4+ years of high-complexity clinical laboratory experience
PREFERRED QUALIFICATIONS
- Master's Degree in cancer genomics, human genetics, or a related biological science required.
- PhD preferred, with strong experience in variant analysis and literature review, clinical report writing, correlation of genomic data with pathology and clinical data.
- At least one year of experience in a diagnostic laboratory setting (CAP accredited, CLIA-certified), including proficiency with variant databases, genome browsers, IGV, and HGVS nomenclature.
- Knowledge of basic computational methods and tools used in NGS.
- Familiarity with NGS data formats (e.g., VCF, BAM), and variant annotation tools
- Familiarity with variant classification guidelines (AMP/ASCO/CAP, ClinGen oncogenicity SOP, AMP/ACMG etc.)
- Familiarity with WHO tumor diagnostics blue book series for solid tumors and hematologic malignancies.
Market Leading Benefits Including*:
- Medical coverage starting day 1 of employment. View employee benefits here.
- Competitive retirement plans
- Tuition reimbursement for continuing education
- Expansive employee discount programs through our many community partners
- Shift Differential, Weekend Differential, and Weekend Option Pay Programs
- Referral bonus program for current staff!
- Support through Employee Resource Groups such as African American Professionals Advisory Council, Asian Cultural and Professional Group, EQUAL - LGBTQA Resource Group, Juntos - Hispanic/Latin Resource Group, Veterans and Military Family Advocacy Network, and Young Professionals (YP) Resource Group
- Physical and mental health wellness programs
- Relocation assistance available for qualified positions
- Benefits may vary based on FTE Status and Position Type
Primary Location
Lincoln Building
Schedule
Full time
Shift
Day (United States of America)
Department
Pathology
Employee Status
Regular
FTE
1
Weekly Hours
40
- Expected Starting Pay Range
- Annualized pay may vary based on FTE status
$72,841.60 - $91,915.20
Comprehensive job description provided upon request.
Cincinnati Children’s is proud to be an Equal Opportunity Employer committed to creating an environment of dignity and respect for all our employees, patients, and families. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, age, genetic information, national origin, sexual orientation, gender identity, disability or protected veteran status. EEO/Veteran/Disability
Read Full Description