Johnson and Johnson

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Pharmacokinetics & Pharmacometrics

Job Category:

Scientific/Technology

All Job Posting Locations:

Beerse, Antwerp, Belgium

Job Description:

Principal Scientist Bioanalytical Assay Development (LBA & LC-MS), BDDS

Johnson & Johnson Innovative Medicine is recruiting for a Principal Scientist, Bioanalytical Discovery & Development Sciences, located in Beerse, Belgium.

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal.

Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow and profoundly impact health for humanity. Learn more at https://www.jnj.com/.

For more than 130 years, an inclusive work environment has been a part of our cultural fabric at Johnson & Johnson and woven into how we do business every day. Guided by Our Credo, this value empowers our commitment to fostering a healthier and more equitable world. Our diverse workforce and culture of belonging accelerate innovation to solve the world’s most pressing healthcare challenges.

We know that the success of our business – and our ability to deliver meaningful solutions – depends on how well we understand and meet the diverse needs of the communities we serve. Which is why we foster a culture of inclusion and belonging where all perspectives, abilities and experiences are valued, and our people can reach their potential.

At Johnson & Johnson, we all belong.

The Development PK team within Bioanalytical Discovery & Development Sciences (BDDS) Department at our research division in Beerse (Belgium) is seeking a bioanalytical assay development expert (Principal Scientist level) with hands-on experience in protein therapeutics (monoclonal Ab, ADCs, fusion proteins, etc) bioanalysis using both LBA and LC-MS approaches. You will provide technical project leadership focused on the development of innovative bioanalytical assays to support J&J's pipeline.

You will be operating in a regulated bioanalytical lab that provides bioanalytical support for First-in-man clinical studies together with a highly collaborative team of scientists.

You will be self-motivated, with proven leadership experience, a track record of innovation, and expertise in protein bioanalysis.

In this exciting role, you will

• Set and influence bioanalytical program strategies across a portfolio of projects and serve as a key contact for communicating technical information effectively across cross-functional teams.
• Be responsible for independently managing functional deliverables for assigned program(s) and for driving the science on a day-to-day basis with broad project goals and capable of making decisions and solving problems of high complexity.
• Design experiments, interpret and track results, and utilize the information to optimize and advance bioanalytical support across bioanalytical platforms.
• Work in a regulated environment, keeping accurate and timely documentation of electronic notebooks and study records.

Education Requirements:

Ph.D. in Chemistry, Biochemistry, Pharmaceutical Sciences or related discipline with a minimum of 4 years of relevant industry experience OR a Master’s with a minimum of 6 years of relevant industry experience.

Required Experience and Skill Set:

• Proven experience in supervising and strategically leading teams to support internal assay development, troubleshooting, validation, and sample analysis.
• Demonstrated ability to design, develop, validate, and execute ECL-based ligand-binding assays for the quantification of proteins, including xenobiotics, biotherapeutics, and biomarkers, in samples from pre-clinical and clinical studies within a regulated environment. Proven proficiency in protein LC-MS analysis and sample preparation techniques, including immunocapture, protein precipitation, and solid-phase extraction (SPE). Expertise also extends to the automation of these processes using Hamilton and KingFisher platforms. Proficient in the upkeep, maintenance, and troubleshooting of bioanalytical instruments such as LC-MS (Sciex) and MSD.
• Demonstrated ability to lead the development of innovative bioanalytical approaches and experimental designs.
• Comprehensive understanding of the drug development process, alongside strong knowledge of bioanalytical guidelines and regulatory requirements (ICHM10), with a focus on method validation and sample analysis.
• Recognized innovator in the fields of mass spectrometry and immunoassays, with excellent verbal and written communication skills.
• Ability to work autonomously in a regulated environment with minimal supervision while fostering a collaborative and inclusive team atmosphere.

Preferred Experience and Skill Set:

• History of publication in peer-reviewed journals and established scientific reputation (including publications, presentations at scientific meetings, membership of or leading cross-company working groups or consortia).
• Understanding of external scientific environment and current state of art instrumentations, and ability to translate that to scientific innovation.
• Ability to multi-task in a highly dynamic environment and flexibility to work in a fast-paced team in a professional and pleasant manner.
• Experience with lab automation.