Yale University

Description

The Jiang Laboratory in the Departments of Genetics at Yale School of Medicine seeks a highly motivated candidate for an Associate Research Scientist position.

About the Lab

The Jiang Laboratory studies neurodevelopmental and neurogenetic disorders caused by genetic or epigenetic defects. The Lab is interested in the clinical presentations of these disorders and the potential new biology implicated. Our ultimate goals are to discover new biology and develop novel therapies for these disorders in humans.

We employ genomics approaches to discover the molecular basis of neurodevelopmental and neurogenetic disorders such as autism spectrum disorder, intellectual disability, Phelan-McDermid, Angelman, and Prader-Willi syndrome. We ask important questions how the deficiency of genes such as SHANK2, SHANK3, UBE3A, TET3, HIST1H1E, and SNORD116 lead to the impairment of neurodevelopment and what are the mechanism at molecular and circuit levels.

We study these questions using in vitro models of patient IPSC derived neurons and brain organoid and in vivo of mutant mice and employ multidisciplinary experimental approach of combing molecular, epigenetic, cellular, synaptic physiology, optogenetics, and behavioral techniques.

Primary Responsibilities:

The ideal candidate must be able to do the following:

• Participate and assist the principal investigator with conducting NIH supported studies and projects on genomic discoveries of rare and undiagnosed disease and developing CRISPR based editing treatments for neurogenetic and neurodevelopmental disorders.
• Conduct experiments related to molecular genetics and epigenetic analysis, CRISPR editing, patient derived IPSC and brain organoids, and phenotypic analyses of mutant mice.
• Must be able to work effectively and enthusiastically in a large team environment.
• Must be prepared to work on genomic studies of rare disease, preclinical and FDA IND studies to develop new treatment, data collection and analysis, research and grant reporting, IRB protocol development, and must be able to communicate with investigators at Yale, other institutes, and program officers at the NIH.
• Must have a demonstrated proven track record of scientific productivity.
• Must have excellent scientific writing and oral communication skills as projects will be highly collaborative.

About the Department

The Department of Genetics believes that diversity drives outstanding science. We strive to create an inclusive community of faculty, staff, and students that promotes and values diversity in age, gender identity, race, sexual orientation, physical or mental ability, and ethnicity to represent better the communities we serve. Please refer to the official Yale School of Medicine statement on diversity and inclusion, accessible here: https://medicine.yale.edu/diversity/

Equal Employment Opportunity Statement

Yale University is an Affirmative Action/Equal Opportunity employer. Yale values diversity among its students, staff, and faculty and strongly welcomes applications from women, persons with disabilities, protected veterans, and underrepresented minorities.

Qualifications

Applicant must hold a Ph.D., or equivalent degree and must have at least two years work experience post degree.

Application Instructions

Applications should include a cover letter, curriculum vitae, a statement of research interests and career goals (up to 2 pages). Complete applications and letters of recommendation should be uploaded through Yale’s Interfolio website: http://apply.interfolio.com/157243

Review of applications will begin immediately and continue until the position is filled. All questions should be addressed to yong-hui.jiang@yale.edu.

Equal Employment Opportunity Statement

The University is committed to basing judgments concerning the admission, education, and employment of individuals upon their qualifications and abilities and seeks to attract to its faculty, staff, and student body qualified persons from a broad range of backgrounds and perspectives.

Additionally, in accordance with this Policy and as delineated by federal and Connecticut law, Yale does not discriminate in admissions, educational programs, or employment against any individual on account of that individual’s sex; sexual orientation; gender identity or expression; pregnancy, childbirth or related conditions; race; color; national or ethnic origin; religion; age; disability; protected veteran status, or other protected classes as set forth in federal and Connecticut law.

Professional Conduct Review for New Faculty Hires

The final candidate, upon acceptance of a contingent offer of employment/faculty appointment, may be required to disclose whether they are, or have been, the subject of any disciplinary proceeding (investigation, hearing, etc.) at previous institutions or employers, and may also be subject to a background screening. Candidates who materially misrepresent information on their resume or other application materials are ineligible for hire/appointment. Final candidates may also be required to sign a release to allow Yale to solicit information regarding any substantiated conduct violations from current and/or past employers.