Amgen

Career Category

Scientific

Job Description

HOW MIGHT YOU DEFY IMAGINATION?

You’ve worked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills, experience and passion to work toward your goals? At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies, reaching over 10 million patients worldwide. Come do your best work alongside other innovative, driven professionals in this meaningful role.

Sr Scientist - Multi-Specific Drug Discovery and Characterization (Contract)

Live

What you will do

Let’s do this. Let’s change the world. In this vital role you will join our Induced Proximity Platform (IPP) team to establish and discover novel multi-specific antibody molecules. The Amgen IPP team specializes in the emerging proximity-based drug discovery for various Oncology, Cardiometabolic, and Inflammation targets. We seek to develop and apply targeted protein degradation approaches to control pathogenic membrane and secreted proteins using multi-specific antibody molecules. The successful candidate will join our highly enthusiastic team of scientists to design, characterize, optimize, and discover multi-specific large molecules. A competitive candidate will have a demonstrated track record of working and publishing high-quality science in a related field and have deep expertise in technical skills. We provide a well-resourced workplace for fast-paced, innovative science collaboratively. This is a permanent role that offers potential for advancement and career development. Successful candidates must reside in the Greater Vancouver area. If you have a passion for antibody engineering and protein degradation science and want to be part of an organization discovering new therapeutic modalities to impact patients’ lives, we invite you to join us!

Essential Functions:

• Design, develop, and establish a multi-specific degrader antibody drug pipeline for secreted and membrane proteins.
• Routinely conduct experiments using cultured mammalian cells and use appropriate assays to characterize and optimize multi-specific degrader antibody molecules.
• Perform quantitative assays for target internalization, localization, and degradation using imaging and other applicable techniques.
• Use multimode plate readers, fluorescence microscopes, flow cytometers, and liquid handlers.
• Manage research projects as needed, keep records of experimental details data results, and present findings to the leadership and cross-functional teams.

Win

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The professional we seek is an individual with these qualifications.

Basic Qualifications:

Doctorate degree

OR

Master’s degree & 4 years of directly related research experience

OR

Bachelor’s degree & 6 years of directly related research experience

Preferred Qualifications:

• Broad knowledge and understanding of cell and molecular biology, including research familiarity with endosomal protein sorting, trafficking, and lysosomal biology.
• Previous experience with the development and characterization of multi-specific antibody molecules, including the design, engineering, and conjugation.
• Deep expertise in quantitative cell-based assays, including Western Blotting, NanoLuc, AlphaLISA, etc
• Demonstrated ability to perform quantitative fluorescence imaging using IncuCyte or high-content imagers.
• Familiarity and experience with CRISPR screens in arrayed or pooled format.
• A highly independent and self-driven scientist who can drive discovery efforts as needed with minimal everyday guidance.
• Eager to work in teams and seek collaboration as required by the project to achieve project goals on time.

Thrive

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for our teammates’ professional and personal growth and well-being.

The annual base salary range for this opportunity in Canada is 104,000 CAD – 144,000 CAD.

In addition to the base salary, Amgen offers the following to staff on contract:

• An option of a comprehensive health benefits package, or an additional 10% “in lieu of benefits” allowance
• Award-winning time-off plans and annual company-wide shutdowns
• Flexible work models, including remote work arrangements, where possible
• Robust Learning and Development opportunities

Apply now

for a career that defies imagination

Objects in your future are closer than they appear. Join us.

careers.amgen.com

Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

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