Who is Saint Louis University? Founded in 1818, Saint Louis University is one of the nation’s oldest and most prestigious Catholic universities. SLU, which also has a campus in Madrid, Spain, is recognized for world-class academics, life-changing research, compassionate health care, and a strong commitment to faith and service.
All About You
An immediate postdoctoral position is available in the lab of Gucan (Gabriel) Dai at the Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine. We are seeking candidates with a solid publication record in biophysics and biochemistry, specifically in the field of ion channels or membrane proteins. Prior experience in patch-clamp electrophysiology or fluorescence cell imaging using advanced fluorescence microscopy techniques is highly preferred.
The Dai lab focuses on investigating the fundamental mechanisms underlying ion channels of excitable membranes, employing a multidisciplinary approach that combines structural biology, chemical biology, genetics, fluorescence microscopy, and electrophysiology. Notably, our lab is equipped with a state-of-the-art frequency-domain fluorescence lifetime imaging microscopy, which is the only one of its kind in the state of Missouri.
We are currently pursuing research directions summarized below:
Investigating the voltage-sensing mechanisms of voltage-gated ion channels that play a crucial role in various diseases such as chronic pain, cardiac arrhythmia, and epileptic seizures. Key techniques for trainees to learn include patch-clamp fluorometry (PCF), Förster resonance energy transfer (FRET), as well as the application of fluorescent noncanonical amino acids (ncAAs).
Elucidating the mechanisms involved in the lipid-mediated regulation of ion channels and the dynamics of lipid membranes, which are critical factors in inflammatory and neuropathic pain, Alzheimer's disease, epilepsy, and viral infections. Additional techniques relevant to this research direction include whole-cell fluorometry, calcium imaging, TIRF microscopy, and fluorescence lifetime imaging.
We highly encourage individuals interested in this position, please apply for the position from the link or contact us at gucan.dai@health.slu.edu.
Function
Medical Research Primary Appointment 12 mo.
Scheduled Weekly Hours:
40
Saint Louis University is an equal opportunity/affirmative action employer. All qualified candidates will receive consideration for the position applied for without regard to race, color, religion, sex, age, national origin, disability, marital status, sexual orientation, military/veteran status, gender identity, or other non-merit factors. We welcome and encourage applications from minorities, women, protected veterans, and individuals with disabilities (including disabled veterans). If accommodations are needed for completing the application and/or with the interviewing process, please contact Human Resources at 314-977-5847.
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