Oxford Nanopore

Oxford Nanopore Technologies is headquartered at the Oxford Science Park outside Oxford, UK, with satellite offices and a commercial presence in many global locations across the US, APAC and Europe.

Oxford Nanopore employs from multiple subject areas including nanopore science, molecular biology and applications, informatics, engineering, electronics, manufacturing and commercialisation. The management team, led by CEO Dr Gordon Sanghera, has a track record of delivering pioneering technologies to the market.

Oxford Nanopore’s sequencing platform is the only technology that offers real-time analysis, in fully scalable formats from pocket to population scale, that can analyse native DNA or RNA and sequence any length of fragment to achieve short to ultra-long read lengths. Our goal is to enable the analysis of any living thing, by anyone, anywhere!

The Details...

The successful candidate will work with wet lab scientists within the Applications team to enable new and improved methods in RNA biology using the nanopore platform. They will implement and evaluate new bioinformatic workflows and tools for dRNA and cDNA sequencing and help design and implement projects striving to demonstrate novel application areas enabled by technology, protocol, and bioinformatics updates. The job holder will also directly support customers with their ONT (bioinformatics) needs by carrying out a range of different analyses (e.g. gDNA, cDNA, dRNA) on external customer ONT-based data as part of Project Support. They also provide best-practice advice internally to other scientist and ONT’s customer facing teams, and may be relied upon to directly present results to external customers, for example as part of project support or at conferences.

Responsibilities include:

• Working independently on the development of pipelines for analysis of applications of cDNA, and direct RNA sequencing using ONT's nanopore sensing platform with support from the Bioinformatics Manager.
• Collaborating closely with scientists and informaticians internally and externally to design, implement, and improve new workflows and tools required for ONT applications, and providing standard process advice on their use.
• Closely collaborating with laboratory-based scientists to help them plan and refine experiments.
• Trouble-shooting new experimental methods, including identifying possible technical factors that influence data quality and implementing new tools or analyses.
• Interpreting data generated in a wide-range of projects in the appropriate biological context and depth.
• Reporting analysis results clearly to bench and dry lab collaborators and other partners, and communicating results in wider team meetings.
• Supporting our customers and customer facing teams to help key accounts overcome analysis obstacles for Project Support.

What We're Looking For...

We'll expect you to have practical experience of handling and analysing large next-generation transcriptomics (cDNA or dRNA) sequencing data sets. You'll also have a history of involvement in the whole experimental process, from the initial experimental concept to execution, analysis, and presentation results, addressing important biological questions. Experience with developing and evaluating bioinformatics tools or workflows for sequencing data analysis, and an understanding of the range and limitations of existing bioinformatics tools. In addition, you have substantial experience with scripting languages (e.g. python, R). You'll have a PhD in a Biological Science or Computer Science with a substantial bioinformatics component, or equivalent experience. Further experience within the biotechnology industry (or a postdoc) involving sequencing data analysis, would be an asset.

Additional skills, experience and knowledge in the following areas are also desirable:

• Experience with long read sequencing data analysis.
• Experience with any of the following analyses is a plus: single-cell RNA sequencing, differential gene expression, RNA isoforms, RNA-modifications, variant calling, DNA methylation analysis, adaptive sampling.
• Proven experience successfully delivering on a range of sequencing projects using different types on experimental protocols or bioinformatic analyses, and running multiple projects effectively in parallel.
• Ability to adapt, modify, and write bioinformatic tools or pipelines to achieve specific outcomes.
• Experience with workflow management systems (e.g. Snakemake, NextFlow) and software development practices (e.g. version control).
• Experience releasing sequencing data analysis tools or workflows you’ve created.
• Large general biological knowledge including molecular biology, RNA biology, and transcriptomics.
• Excellent scientific literacy and proven scientific writing skills.
• Experience with presenting scientific results to varied scientific audience.
• Hands-on wet lab experience or a track record of interaction with wet lab scientists.
• Experience with simple sample and library preparation for NGS.

We offer outstanding benefits to include an attractive bonus, generous pension contributions, private healthcare and an excellent starting salary. Based within beautiful, landscaped surroundings with tree-lined walks, water features and a lake, all of which make for a wonderful working environment.

If you are looking to utilise your skills to really make a difference to humankind, then consider joining our team and apply today!

Please note that no terminology in this advert is intended to discriminate on the grounds of a person's gender, marital status, race, religion, colour, age, disability or sexual orientation. Every candidate will be assessed only in accordance with their merits, qualifications and abilities to perform the duties of the job.

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Oxford Nanopore’s goal is to bring the widest benefits to society through enabling the analysis of anything, by anyone, anywhere. The company has developed a new generation of nanopore-based sensing technology enabling the real-time, high-performance, accessible and scalable analysis of DNA and RNA. The technology is used in more than 100 countries to understand the biology of humans and diseases, plants, animals, bacteria, viruses and whole environments.

Oxford Nanopore was founded in 2005 as a spin-out from the University of Oxford and now employs around 650 employees around the world.