Genentech

The Opportunity:

This position, based in Genentech's Oceanside, California facility, provides the opportunity to have a key role in a highly automated pharmaceutical drug substance facility. The site employs highly integrated computer control systems to manage plant operations and manufacturing data. The candidate will report to the Site Head of IT OT, an organization that is currently undergoing a transformation towards digitalization, advancing fundamental elements to meet future needs, such as standardizing and leveraging new technologies.

As part of the Oceanside IT OT team, you will have accountabilities for the Oceanside Manufacturing Execution System (MES), maintaining roadmaps and lifecycle plans, developing proposals, managing related backlogs, leading and/or participating in Build/Run Squads, and ensuring the support of Product Transfers and Make/Assess/Release in a 24x7 Good Manufacturing Practice (GMP) environment. As part of the Site Team and larger Global IT OT organization, you will also be expected to contribute to Manufacturing Operations Management initiatives and optimization/standardization of the global IT OT landscape.

What you’ll be working on:

Database Development & Administration

• Design, implement, and optimize SQL Server databases supporting MES.
• Develop complex SQL queries, stored procedures, functions, and triggers.
• Perform database tuning, indexing, and query optimization for performance and scalability.
• Manage backups, restores, disaster recovery plans, and high-availability configurations.
• Build data extracts and reporting views for manufacturing and quality stakeholders.

MES Application Engineering

• Configure, deploy, and maintain MES software (Emerson Syncade or Pharamsuite).
• Lead MES upgrades, patch management, and change controls.
• Troubleshoot MES application issues across the stack (UI, middleware, backend).

Systems & Infrastructure Administration

• Manage Active Directory integration, user/group access control, and system security.
• Monitor server performance, capacity, and uptime with proactive alerts and logs.
• Support virtualization (VMware) and system redundancy for critical GMP applications.

Compliance & Validation

• Ensure systems meet GxP and FDA 21 CFR Part 11 requirements.
• Author/execute technical validation documents (URS, FRS, DS, IQ/OQ/PQ).
• Support internal and external audits by providing technical and compliance evidence.

Cross-Functional Collaboration

• Integrate MES with ERP, LIMS, DCS, and automation systems.
• Partner with Manufacturing, QA, Validation, and IT teams to deliver compliant, efficient solutions.
• Mentor junior engineers on SQL/database best practices, MES configuration, and system administration.

Who you are:

• 5 - 6 years of MES experience in biotech, pharma, or other GMP-regulated manufacturing.
• Advanced SQL Server skills (query optimization, schema design, indexing, performance tuning).
• Strong Windows Server and Active Directory administration.
• Hands-on experience with MES platforms ( Emerson Syncade or Pharmasuite).
• Proven ability to troubleshoot system issues across multiple layers (application, DB, OS, infrastructure).
• Strong understanding of GxP, GMP ( CSV methodologies optional )

Preferred Technical Skills

• Scripting/automation (PowerShell, Python, or Bash).
• Experience with virtualization platforms (VMware, Hyper-V).
• Reporting/analytics tools (Crystal Reports).
• Knowledge of integrating MES with automation and shop floor systems (OPC).

Relocation benefits are not available for this job posting.

Pay transparency

The expected salary range for this position based on the primary location of Oceanside is $80,500.00 - $149,500.000 USD Annual. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.