Senior Principal Scientist, Discovery Biotherapeutics, Selection Technologies

Bristol-Myers Squibb Company

Working with Us

Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

Senior Principal Scientist, Discovery Biotherapeutics, Selection Technologies

Summary

The Discovery Biotherapeutics team is dedicated to the discovery and advancement of novel biotherapeutic candidates, leveraging cutting-edge science and innovative technologies to drive the drug discovery pipeline. We seek to understand the structure and function of complex molecules such as bispecific antibodies, antibody drug conjugates, and endogenous proteins in order to optimize their utility as therapeutic agents. Our team collaborates across disciplines to advance biologic programs in Oncology, Immunology, Cardiovascular, and Neuroscience with the ultimate goal of bringing new groundbreaking therapies to patients. The Selection Technologies team, a key component of Discovery Biotherapeutics, harnesses the power of in vitro display technologies such as yeast and mRNA display to discover binders against therapeutic targets of interest. We collaborate closely with computational biologists embedded directly in the Discovery Biotherapeutics organization to apply AI/ML predictions to synthetic library design, Next Generation Sequencing (NGS) analysis, and therapeutic candidate prioritization.

Position Responsibilities

The role of Senior Principal Scientist within Discovery Biotherapeutics, Selection Technologies involves leading a high-performing team that is responsible for conducting selections using in vitro display platforms such as yeast and mRNA display to discover binders against targets of interest. The successful candidate will be an expert in antibody discovery from in vitro methods and play a prominent role in shaping the future direction of platform development and innovation in this area. The role requires exceptional leadership and mentoring skills and the ability to collaborate across functional areas to support and potentially lead therapeutic programs.

In the role as a Senior Principal Scientist within Discovery Biotherapeutics, Selection Technologies, the ideal candidate will:

  • Lead a team of scientists to drive therapeutic antibody discovery efforts and foster a collaborative, goal-oriented environment.
  • Lead technology innovation efforts to benchmark and evolve our in vitro display platform and drive strategic decisions around synthetic library designs and platform investments.
  • Collaborate closely with computational and data science colleagues to leverage AI/ML and other computational methods applied to biotherapeutic discovery and to generate new ways of analyzing data.
  • Drive binder discovery and selection strategy across therapeutic programs.
  • Leverage cross-functional collaboration skills to lead therapeutic projects and/or technology initiatives.

Experience - Basic Qualifications

  • Bachelor’s Degree
    • 10+ years of academic and/or industry experience

Or

  • Master’s Degree
    • 8+ years of academic and/or industry experience

Or

  • Ph.D. or equivalent advanced degree in the Life Sciences
    • 6+ years of academic and/or industry experience
    • 2+ years of leadership experience

Experience - Preferred Qualifications

  • Ph.D. or equivalent with 6+ years of industry experience and 4+ years of leadership experience.
  • Technical expertise in performing and supervising in vitro display experiments, including yeast, mRNA, phage, and/or mammalian display platforms.
  • Experience implementing and/or building in vitro antibody discovery platforms, such as designing synthetic antibody libraries or developing new in vitro display systems.
  • Experience analyzing antibody variable region sequences, including data from Next Generation Sequencing (NGS).
  • Experience leading therapeutic projects or technology initiatives that involve cross-functional matrix teams.
  • Exceptional interpersonal and communication skills, with the capability of leading and developing a high-performing experimental team.
  • Demonstrated ability to attract and retain top talent, and a commitment to talent development and diversification.
  • Proven track record of scientific innovation, peer-reviewed publications, and IP generation is a plus.
  • Experience working with generative binder methods and structure-enabled design is a plus.
  • Experience with multiple antibody formats, including Fab, scFv, and single domain/VHH is a plus.
  • Proven leadership and experience managing matrix research teams and advancing biologics binder generation or therapeutic programs is a plus.

The starting compensation for this job is a range from $184,720 - $223,800, plus incentive cash and stock opportunities (based on eligibility).

The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation will be decided based on demonstrated experience.

Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit our BMS Careers Site.

Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown days between Christmas and New Year’s holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.

If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers

With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

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Confirmed an hour ago. Posted 3 days ago.

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