Bristol-Myers Squibb Company

Working with Us

Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

Position Summary

The Principal Scientist will serve as a drug product analytical lead who will drive analytical strategy and support for small molecule drug product development activities. The incumbent will be accountable as an individual contributor and as an analytical matrix team lead to support analytical method development as well as providing analytical characterization support for drug product formulation and process development activities. The Principal Scientist will play an integral role as part of the drug product development organization and will provide necessary guidance and support of drug product control strategy for drug candidates across all stages of development and, as needed, within the commercial product portfolio. The individual will be proficient in multiple analytical techniques as well as with the latest ICH, FDA and EMA regulatory guidance on pharmaceutical development. The individual will be a member of a cross functional team responsible for drug product related CMC strategy development.

Key Responsibilities

The Principal Scientist will collaborate across BMS sites with Analytical, Drug Product, Drug Substance, Quality, and Regulatory leads to execute drug product formulation/process development support, analytical strategies for drug product methods and specifications, analytical control strategies, and support of product development up to drug application submissions and approval.

• Support drug product formulation and process development including characterization of the process and finished product.
• Develop and optimize drug product analytical methods and provide guidance to QC during validation and transfer.
• Conduct and assess developmental stability experiments to inform formulation design and packaging selection for drug products.
• Provide matrix leadership for scientific staff. Develop, coach and mentor others.
• Will serve on a cross functional team responsible for analytical related CMC strategy development.
• Review and discuss analytical results and conclusions both orally and in writing.
• Write formal reports as source documents for inclusion in regulatory filings and support the generation of appropriate responses to questions from regulatory authorities.

Qualifications & Experience

Required:

• Experience in the development and performance of analytical tests for a variety of drug products dosage forms.
• Extensive knowledge of HPLC / UPLC method development.
• Knowledge of dissolution method development and testing, biorelevant dissolution testing and biopharmaceutical classification system.
• Experience with LC/MS analysis and application to analysis of nitrosamine impurities in drug products
• Strong knowledge of chemistry with extensive expertise in measurement science.
• Understanding of drug product formulation and process development principles.
• Experienced in building the CMC dossier for regulatory submissions as an author/reviewer.
• Prior experience as an analytical development matrix leader.

Ideal Candidates Would Also Have:

• Exceptional verbal and written communication skills and interpersonal skills as a team member/leader in an environment where individual initiative, collaboration and accountability are valued.
• Familiar with modern laboratory equipment and automation.
• Understands and applies Quality by Design and other statistical principles.

Other Qualifications:

• Completed BS and 9-12 years; MS and 6-9 years; or Ph.D. and 4-6 years in Chemistry (or relevant discipline) with pharmaceutical laboratory experience.
• A demonstrated record of scientific accomplishment, laboratory experimentation, publication, and presentation.
• Understands PAT and risk assessment approaches.

Development Value:

• The Principal Scientist will have organizational and interdepartmental responsibilities with regards to leading workgroups, cross-functional teams, strategy development/ implementation/execution, and cultural initiatives.

The starting compensation for this job is a range from $138,190 - $167,500, plus incentive cash and stock opportunities (based on eligibility). The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed.

Final, individual compensation will be decided based on demonstrated experience.

Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/

Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Year’s holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.

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If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers

With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/

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