AbbVie

Salary Min: 94000

Salary Max: 178500

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

Job Description

We are seeking a highly motivated Senior Scientist I with a diverse protein biochemistry background to join our Protein Analytics team within our Biotherapeutic Discovery Production group. The team is responsible for characterizing purity and key product quality attributes of candidate molecules to advance those with the greatest probability of success as well as guiding protein engineering and production path development activities.

The successful candidate will be focused on implementing and conducting various assays to monitor process impurities and to assess the function of Biotherapeutics with the aim of fully characterizing lead/candidate molecules and identifying potential molecular liabilities. Some of the techniques/methods utilized in the position include 1) released glycan assay (RGA) using BioAccord LC-MS system; 2) surface plasmon resonance (SPR) using Biacore for assessment of antigen binding and binding of antibody Fc receptors; and 3) isoelectric focusing (IEF) and capillary electrophoresis (CE). The role also includes assessment of thermal/chemical stability to extend understanding of potential liabilities and inform engineering efforts and candidate selection. The position will be responsible for developing and implementing new technologies/platforms that improve the efficiency of the overall drug-discovery process for multispecific therapeutic proteins as well as data tracking and reporting and will require collaboration with the production group and other analytics teams.

Key Responsibilities:

• Implement and conduct assays to monitor process impurities and to assess the function of Biotherapeutics such as RGA, SPR, IEF, CE-SDS, etc.
• Identify, develop, and implement new technologies/platforms that improve the efficiency of the overall drug-discovery process for multispecific therapeutic proteins.
• Maintain a high level of productivity in the lab, conducting research independently and managing several projects simultaneously. Independently design, execute, and interpret experimental results. Caretaking and troubleshooting key instrumentation.
• Optimize workflows to address evolving timelines and priorities by integrating automation into platform methods.
• Contribute to project teams and work effectively across functional groups to help advance programs.
• Stay current with applicable internal/external scientific literature and apply new information in innovative ways to successfully complete work assignments.
• Routinely demonstrate scientific initiative and creativity in research activities.
• Demonstrates high proficiency across a wide range of relevant technologies.
• Analyze, document, and report data concisely and rigorously.

Qualifications

• BS, MS, or Ph.D. in Biochemistry, Biophysics, Analytical Chemistry, or related field with typically 0-4 years (with PhD), 8-10 years (with MS), or 10-12 years (with BS) of experience.
• Demonstrated skill in RGA to characterize glycan profiles of biologic drug candidate molecules is a must.
• Must be proficient in SPR analysis to characterize target binding attributes of novel Biotherapeutics.
• Well versed in other techniques to assess quality attributes of biotherapeutic molecules such as IEF and CE-SDS, for example.
• Ability to deliver near “real-time” analytical results to guide the biotherapeutic candidate production process path is required.
• Demonstrated ability to oversee, maintain, and troubleshoot lab equipment.
• Should possess excellent communication skills and be proficient in presenting in front of groups.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible to participate in our short-term incentive programs.

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

https://www.abbvie.com/join-us/reasonable-accommodations.html