Caris Life Sciences

At Caris, we understand that cancer is an ugly word—a word no one wants to hear, but one that connects us all. That’s why we’re not just transforming cancer care—we’re changing lives.

We introduced precision medicine to the world and built an industry around the idea that every patient deserves answers as unique as their DNA. Backed by cutting-edge molecular science and AI, we ask ourselves every day: “What would I do if this patient were my mom?” That question drives everything we do.

But our mission doesn’t stop with cancer. We're pushing the frontiers of medicine and leading a revolution in healthcare—driven by innovation, compassion, and purpose.

Join us in our mission to improve the human condition across multiple diseases. If you're passionate about meaningful work and want to be part of something bigger than yourself, Caris is where your impact begins.

Position Summary

The Senior Automation Engineer will be a subject matter expert of the liquid handler systems. They will assist in design, development, validation, and support of scripts/methods as appropriate. This includes but is not limited to requirements/specifications gathering, method development, liquid class development/testing, method validation, assist with IQ, OQ, PQ procedures and documentation. The Senior Automation Engineer is also responsible for optimizing methods, ensuring system functionality, and communicating with lab personnel regarding system development and status. The ideal candidate will have hands-on laboratory experience, a minimum of 3 years scripting in liquid handlers and knowledge of NGS workflows.

We are seeking an individual with an excellent work ethic, great attention to detail and desire for continuous skill development. The engineer is expected to be on site, design and develop automated methods, validate systems, practice GMP standards, train and support additional engineers as appropriate.

Job Responsibilities

• Modify, create, implement, and validate scripts/methods on liquid handlers
• Provide expertise in all liquid handler matters
• Provide solutions to optimize methods/workflows
• Evaluate new technologies as appropriate
• Ensure instruments/methods are validated in accordance with regulatory requirements
• Develop/optimize/validate custom liquid classes to ensure proper volume delivery
• Stress test systems/methods to ensure robustness of method functionality
• Commit to continuous improvement
• Drive other directives and initiatives; accepting additional responsibilities as assigned.

Required Qualifications

• Bachelor’s Degree in engineering, science related fields.
• Proficiency in liquid handler scripting (Tecan, Hamilton, Bravo, etc.). (3+ years)
• Proficiency in liquid class development and testing
• Extraordinary communication and interpersonal skills
• Exceptional project management and time management skills; ability to multi-task and work in a fast-paced environment.
• Must be able to articulate proposed solutions and associated benefits across stakeholders.
• Keen ability to conceptualize, analyze and implement new processes/ process changes.
• Experience must encompass method design and development as well as liquid class optimization.

Preferred Qualifications

• ASCP Certification
• 2+ years working in CAP/CLIA/FDA regulated laboratory

Physical Demands

• Must possess ability to sit, stand, and/or work at a computer for long periods of time.
• May have exposure to blood-borne pathogens, extreme temperatures, high noise levels, fumes and bio-hazardous material/chemicals including formalin in the lab environment.

Conditions of Employment: Individual must successfully complete pre-employment process, which includes criminal background check, drug screening, credit check ( applicable for certain positions) and reference verification.

This job description reflects management’s assignment of essential functions. Nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time.

Caris Life Sciences is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, gender, gender identity, sexual orientation, age, status as a protected veteran, among other things, or status as a qualified individual with disability.