Denali Therapeutics

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.

We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.

This position will carry out oligonucleotide analytical development to support our Oligonucleotide Transport Vehicle (OTV) platform. This is an exciting and unique opportunity to contribute to several programs and position us for the future as our groundbreaking OTV therapeutics enter the clinical phase.

Key Accountabilities/ Core Job Responsibilities:

• Develop and validate suitable methods and carry out analytical testing and characterization of oligonucleotides and their starting/ raw materials.
• Analyze and interpret results, using familiarity with oligonucleotide synthesis and purification processes to develop an understanding of fate and purge of impurities.
• Stay up to date with relevant scientific literature and be adept at use of search tools
• Explore innovative analytical technologies to enhance understanding of oligonucleotide processes and molecular properties
• Set up and operate internal oligonucleotide analytical laboratory capabilities
• Collaborate with discovery scientists, process chemists, quality, and project teams to advance our portfolio and analytical strategies and ensure timely flow of information
• Transfer methods and manage activities at partner CDMOs, as necessary (travel may be required).
• Author and/or review analytical data, specifications, Certificates of Analysis, method validation protocols and reports. Define regulatory strategy and author relevant CMC sections of regulatory agency submissions.

Qualifications/Skills:

• Ph.D. in Analytical Chemistry or related scientific discipline, with a minimum of 3 years of relevant experience or M.Sc./B.Sc. with 7 – 12 years of relevant experience, with a record of scientific leadership and innovation as demonstrated by publications and/or patents
• Deep understanding of and demonstrated excellence in analysis of oligonucleotides and their starting materials. Expertise in mass spectrometry is expected
• Knowledge of stage-appropriate QC/analytics relevant to oligonucleotide analysis
• Strong written and verbal communication skills
• Highly organized with the ability to plan and achieve research goals in an organizationally diverse research environment. The candidate should embrace an innovative, non-hierarchical approach to our high-energy start-up environment

Salary Range: $138,000.00 to $174,000.00 . Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at https://www.denalitherapeutics.com/careers

This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.

Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.