PostDoctoral Research Fellow, James Ernst Lab, Genentech Research

Roche

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United States, California, South San Francisco

  • Job facts

We are seeking a highly motivated postdoctoral research fellow to join the Ernst and Hoogenraad Labs in the Departments of Protein Chemistry and Neuroscience within Genentech’s Research and Early Development organization. The ideal candidate for the position will use a variety of biochemical, cell biology and biophysical techniques to understand the fundamental processes of trafficking, endocytosis and/or receptor-ligand interactions.

The Ernst Lab focuses on the areas of large molecule drug development, particularly in the area neurodegenerative disease. Among our interests, is the tissue targeting of biologic molecules, antibodies and signaling molecules. A long-term goal of the group is to understand how antibodies traffic within tissues, especially at the blood-brain barrier, and to identify novel drug targets or methods to improve the potency of therapeutic candidates against existing targets.

Selected publications form the Ernst Lab:

Selective Homogeneous Assay for Circulating Endopeptidase Fibroblast Activation Protein (FAP). Bainbridge, T. W., Dunshee, D. R., Kljavin, N. M., Skelton, N. J., Junichiro Sonoda, J., and Ernst, J. A. (2017) Scientific Reports

Effector attenuating substitutions that maintain antibody stability and reduce toxicity in mice. Lo M, Kim HS, Tong RK, Bainbridge TW, Vernes JM, Zhang Y, Lin YL, Chung S, Dennis MS, Zuchero YJ, Watts RJ, Couch JA, Meng YG, Atwal JK, Brezski RJ, Spiess C, Ernst JA. J Biol Chem. 2017 Jan 11.

Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor. Dunshee DR, Bainbridge TW, Kljavin NM, Zavala-Solorio J, Schroeder AC, Chan R, Corpuz R, Wong M, Zhou W, Deshmukh G, Ly J, Sutherlin DP, Ernst JA, Sonoda J. 21. J Biol Chem. 2016 Mar 11;291(11):5986-96.

Crossing the Blood-Brain Barrier in Non-Human Primates with TfR Bispecific Antibodies. Sci Transl Med. Yu YJ, Atwal JK, Yin Zhang, Tong RK, Wildsmith KR, Tan C, Bien-Ly N, Hersom MMaloney JA, Hoyte K, Luk W, Lu Y, Ernst JA, Couch JA, Dennis MS, and Watts RJ. 2014 Nov 5;6(261):261ra154. doi: 10.1126/scitranslmed.3009835.

Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies. Zuchero YJ, Chen X, Bien-Ly N, Bumbaca D, Tong RK, Gao X, Zhang S, Hoyte K, Luk W, Huntley MA, Phu L, Tan C, Kallop D, Weimer RM, Lu Y, Kirkpatrick DS, Ernst JA, Chih B, Dennis MS, Watts RJ. Neuron. 2016 Jan 6;89(1):70-82.

Molecular Mechanisms of Alzheimer's Disease Protection by the A673T Allele of Amyloid Precursor Protein. Maloney JA, Bainbridge T, Gustafson A, Zhang S, Kyauk R, Steiner P, van der Brug M, Liu Y1, Ernst JA*, Watts RJ*, Atwal JK. J Biol Chem. 2014 Sep 24. pii: jbc.M114.589069.

Selected publications form the Hoogenraad Lab:

Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization. Tortosa E, Adolfs Y, Fukata M, Pasterkamp RJ, Kapitein LC, Hoogenraad CC. Neuron. 2017 May 17;94(4):809-825.e7. doi: 10.1016/j.neuron.2017.04.042.

DeActs: genetically encoded tools for perturbing the actin cytoskeleton in single cells.
Harterink M, da Silva ME, Will L, Turan J, Ibrahim A, Lang AE, van Battum EY, Pasterkamp RJ, Kapitein LC, Kudryashov D, Barres BA, Hoogenraad CC, Zuchero JB.
Nat Methods. 2017 May;14(5):479-482. doi: 10.1038/nmeth.4257. Epub 2017 Apr 10.

Probing cytoskeletal modulation of passive and active intracellular dynamics using nanobody-functionalized quantum dots. Katrukha EA, Mikhaylova M, van Brakel HX, van Bergen En Henegouwen PM, Akhmanova A, Hoogenraad CC, Kapitein LC. Nat Commun. 2017 Mar 21;8:14772. doi: 10.1038/ncomms14772.

Quantitative Map of Proteome Dynamics during Neuronal Differentiation. Frese CK, Mikhaylova M, Stucchi R, Gautier V, Liu Q, Mohammed S, Heck AJR, Altelaar AFM, Hoogenraad CC. Cell Rep. 2017 Feb 7;18(6):1527-1542. doi: 10.1016/j.celrep.2017.01.025.


For more information on James Ernst lab, please visit:
https://www.gene.com/scientists/our-scientists/james-ernst

Information about the postdoctoral program at Genentech can be found at:
http://www.gene.com/careers/academic-programs/postdocs

  • Who you are
    You’re someone who wants to influence your own development. You’re looking for a company where you have the opportunity to pursue your interests across functions and geographies. Where a job title is not considered the final definition of who you are, but the starting point.

    • We are looking for a candidate with a PhD degree in biophysics, biochemistry, cell biology or related field and with a background topics such as protein engineering, biochemistry, protein transport and gene function identification as applied to neurodegenerative disease.
    • The successful applicant will have a demonstrated record of innovative scientific accomplishments as evidenced by at least one first-author paper published or accepted in a reputable journal.
    • Relentless drive and creativity to tackle complex biological questions, enthusiasm to collaborate and learn new technologies, rigorous scientific aptitude, and strong communication and organization skills are essential qualities.

    *LI-gRED-GL1
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  • Who we are
    A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

    Roche is an equal opportunity employer and strictly prohibits unlawful discrimination based upon an individual’s race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, mental/physical disability, medical condition, marital status, veteran status, or any other characteristic protected by law.

    If you have a disability and need an accommodation in connection with the on-line application process, please email us at US.Accommodation@roche.com.
    EEO is the Law

    PAY TRANSPARENCY NONDISCRIMINATION PROVISION
    The contractor will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. However, employees who have access to the compensation information of other employees or applicants as a part of their essential job functions cannot disclose the pay of other employees or applicants to individuals who do not otherwise have access to compensation information, unless the disclosure is (a) in response to a formal complaint or charge, (b) in furtherance of an investigation, proceeding, hearing, or action, including an investigation conducted by the employer, or (c) consistent with the contractor’s legal duty to furnish information. 41 CFR 60-1.35(c)
  • Job facts
    • Location United States, California, South San Francisco
    • Function Research
    • Subfunction Internship/Trainee Research/post-doc
    • Schedule Full-time
    • Job level Individual Contributor
    • Job type Regular Employee
    • Division Roche Pharmaceuticals
    • Posted since 2017/10/18
    • Job-ID 3425944308
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  • We are looking for a candidate with a PhD degree in biophysics, biochemistry, cell biology or related field and with a background topics such as protein engineering, biochemistry, protein transport and gene function identification as applied to neurodegenerative disease.
  • The successful applicant will have a demonstrated record of innovative scientific accomplishments as evidenced by at least one first-author paper published or accepted in a reputable journal.
  • Relentless drive and creativity to tackle complex biological questions, enthusiasm to collaborate and learn new technologies, rigorous scientific aptitude, and strong communication and organization skills are essential qualities.

  • Location United States, California, South San Francisco
  • Function Research
  • Subfunction Internship/Trainee Research/post-doc
  • Schedule Full-time
  • Job level Individual Contributor
  • Job type Regular Employee
  • Division Roche Pharmaceuticals
  • Posted since 2017/10/18
  • Job-ID 3425944308

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