POSITION OBJECTIVE
Working under general supervision, the Research Assistant 2 will work with other staff and trainees in the lab to carry out research projects related to the development of biomarker assays for neurodegenerative diseases. The Kraus lab studies the misfolded protein seeds of neurodegenerative diseases including Alzheimer’s, Parkinson’s disease and Lewy body dementias, chronic traumatic encephalopathy, and prion diseases. The lab uses existing and newly developed ultrasensitive diagnostic assays to measure protein seeds in human samples. The lab also uses cryo-electron microscopy, cellular, and animal models to understand the structural underpinnings and biological mechanisms that contribute to the formation and accumulation of neurodegenerative disease-associated protein seeds. This position may work with animals.
ESSENTIAL FUNCTIONS
NONESSENTIAL FUNCTIONS
Perform other duties as assigned.
CONTACTS
Department: Daily contact with supervisor or designated lab staff to discuss research and maintain workflow.
University: Occasional contact with other departments to share information.
External: Occasional contact with vendors to exchange information.
Students: Frequent contact with student employees to exchange information.
SUPERVISORY RESPONSIBILITY
This position has no direct supervision of staff employees. Train new staff; direct the work of students.
QUALIFICATIONS
Education and experience: bachelor's degree and 1 to 3 years of related experience or associate's degree in an approved biotechnology program and 2 to 4 years of experience.
REQUIRED SKILLS
WORKING CONDITIONS
Standard laboratory conditions with some hazardous chemicals. Special hazards include biohazardous (potentially infectious) human brain and cerebrospinal fluid. The following personal protective equipment required: appropriate gloves, protective eyewear, laboratory coat, and safety shoes.
The lab is an open floor plan with abundant bench space for biochemistry and molecular biology experiments. Ample desk space with computers is also provided. Cell culture spaces are equipped with incubators, biosafety cabinets, and microscopes. Equipment for RT-QuIC reagent preparation and analysis, including an FPLC and multiple plate readers are available within the lab space. The lab is equipped with shared fume hood spaces for handling and storage of hazardous and non-hazardous materials. Major physical demands include standing/sitting for extended periods of time for experimental benchtop work.
Case Western Reserve University's animal facilities are accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care (AAALAC) and is managed according to the "Guide for the Care and Use of Laboratory Animals” appropriate Federal Animal Welfare Regulations, and the Public Health Service “Policy on the Humane Care and Use of Laboratory Animals." This position, and all animal research personnel, are subject to internal compliance to SOM Animal Resource Center Standard Operating Procedures and to compliance regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines, the State of Ohio Veterinary Practice Act, Federal Drug Enforcement Administration regulatory guidelines, US Food and Drug Administration Center for Veterinary Medicine regulations and other applicable regulatory guidelines.
In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.
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Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Equity at 216-368-3066 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.
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