Bioinformatics Research Scientist / Clinical Genome Analyst - Multiple Positions

St. Jude Children's Research Hospital

Summary:

The department of Computational Biology is looking for MULTIPLE highly motivated and creative Bioinformatics Research Scientists to develop and apply innovative analytical and visualization approaches for studying and understanding the genetic variants and epigenetic modifications that drive pediatric cancers and other childhood diseases. The Bioinformatics Research Scientists will contribute ideas to automate and improve existing analysis methods, assist in preparing and submitting manuscripts for publication and assist with establishing and documenting protocols or best practices for common research tasks. Recognized as a world leader in mapping the genetic landscape of pediatric cancers, the St. Jude department of Computational Biology has developed state-of-art computational infrastructure, well-established analytical pipelines, and deep genomic analysis expertise with a track record of high-impact publications in top-tier biomedical journals such as Nature, NEJM, JAMA, Nature Genetics and Nature Methods. The department provides a highly interactive environment with collaborative opportunities across basic and clinical departments, access to high performance computing clusters, cloud computing environment, innovative visualization tools, highly automated analytical pipelines and mentorship from faculty scientists with deep experience in data analysis, data management and delivery of high-quality results for highly competitive projects. This position is located in Memphis, TN, and relocation assistance is available.

Responsibilities:

Positions are available in the department of Computational Biology with the following focus:

  • We are seeking a highly motivated individual to join our cutting edge Clinical Cancer Genomics team. As a clinical genome analyst, you will analyze and classify somatic and germline genetic alterations in pediatric cancer patients ascertained from whole-genome, whole-exome and transcriptiome sequencing and present findings to pathologists, oncologists and genetic counselors. This scientist will also work closely with our bioinformatics pipeline and visualization teams to explore novel analysis approaches that aid molecular classification and clinical reporting. The successful candidate will also have opportunities to participate in research projects to analyze the pediatric cancer genome and epigenome. Our ideal candidate has a deep understanding of cancer biology and expertise in genomic and/or transcriptomic data analysis either through NGS or molecular pathology approaches. We are particularly interested in individuals with expertise in the interpretation of structural and copy number changes in cancer genomes. Prior experience within in a clinical environment and experience in clinical test development and validation is also highly desirable.

    Job Preferences

    PhD in a field directly related to cancer biology with a strong desire to work in a clinical environment. AND Experience with programming languages such as Bash, Perl, Python and R

  • Designing and implementing novel scientific visualization features and expanding the data content for our pediatric cancer genomic data portal initiative (https://pecan.stjude.org/proteinpaint). We are looking for a talented and highly motivated candidate to join our portal development team to help enrich and organize data content, develop innovative data visualization solutions and interact with the Clinical Genomics team and other translational research teams to ensure broad applicability of the visualization tools for use in research and clinical studies. The ideal candidate will have a strong background with high-throughput data analysis and interest in data visualization. Prior experience in developing scientific visualization tools is a highly preferred. A candidate with PhD in Computer Science but no prior experience in cancer research will be considered, but should have strong interest in cancer research and motivation to learn cancer genomic data analysis. The candidate is expected to be a critical thinker and a quick learner. Expertise in data analysis using R and databases such as MySQL and PostgreSQL is also highly desirable.

Candidates at varying levels of their career will be considered. Please include a cover letter expressing your interest in a specific project or research area.

Minimum Education:

PhD in Molecular Biology, Biochemistry, Computer Science, Statistics, Mathematics, Bioinformatics or related field required.

Minimum Experience:

PhD which must include research related to bioinformatics (such as analysis of RNA-seq, WGBS, ChIP-seq, image data, proteomics data, or biological pathways; development of algorithms, statistical methods, or scientific software).

--OR--

If PhD with no bioinformatics research, then two (2) years of pre-or postdoctoral experience in Computational Biology or Bioinformatics research is required.

 

Experience with programming languages such as Perl, Python, C, or Java required.

 

Experience and knowledge on statistical analysis package such as R, SAS and Matlab is highly desired.

 

 

Memphis - A Great Place to Live & Work

St. Jude is based in Memphis, TN with relocation assistance available if needed. Memphis is a family-friendly metropolitan area that more than one million people call home. Memphis is recognized for its world-class music, food and hospitality. Cost of living is one of the biggest attractions; in fact Money listed Memphis as one of the least expensive cities in which to raise a child. 

 

EEO:

St. Jude is an Equal Opportunity Employer

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Confirmed a day ago. Posted 30+ days ago.

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