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Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.

Job Description

The Biologics Preformulation Group is an integral part of the CMC Drug Product Development Organization at AbbVie. The primary function of the Preformulation Group is to evaluate the physicochemical properties of discovery-stage biologic drug candidates, identify liabilities, and to help select lead candidates for further pipeline advancement. We have an exciting opportunity for a motivated scientist to join the AbbVie Preformulation Group based in Worcester, MA. 

Key Responsibilities:

  • Conduct laboratory-based analytical biochemistry and formulation research activities with biologic drug candidates. Perform experiments to screen physicochemical properties of new biologic entities (antibodies, bispecific antibodies, antibody drug conjugates, fusion proteins, AAVs) and identify liabilities that could impact drug development.
  • Execute experimental protocols, collect results, and perform data analysis independently.
  • Maintain excellent documentation of all work including electronic lab notebook and protocols.
  • Prepare and deliver concise scientific presentations of experimental results and assist in authoring detailed scientific technical reports.
  • Stay current with the scientific literature and support new scientific initiatives.
  • Oversee maintenance of key laboratory equipment and routine laboratory operations.
  • Build strong relationships with other team members and across groups.
  • Understand and adhere to corporate standards regarding code of conduct, safety, and GxP compliance.

Qualifications

Qualifications

Job level will be commensurate with experience

  • BS or MS in Biochemistry, Chemistry or related field (e.g., Pharmaceutical Sciences, Chemical Engineering) required
  • Scientist I minimally requires BS + 5 years or MS + 2 years of related experience
  • Scientist II minimally requires BS + 7 years or MS + 5 years of related experience
  • Biopharmaceutical industry experience preferred
  • Hands-on experience in protein biochemical and biophysical characterization, accelerated stability studies, developability assessment of diverse biologic formats (monoclonal antibodies, bispecific antibody formats, antibody drug conjugates, fusion proteins, AAVs, LNPs).
  • Detailed knowledge of protein structure, protein purification, biophysical characterization, and formulation screening.
  • Strong expertise in protein biophysical and biochemical characterization techniques, including size-exclusion, ion e xchange and h ydrophobic i nteraction c hromatography, differential scanning calorimetry/fluorimetry, dynamic light scattering, UV-VIS and fluorescence spectroscopy, imaged capillary isoelectric focusing, capillary electrophoresis, particle and viscosity measurements. Experience in molecular biology, adeno-associated viruses (AAVs), lipid nanoparticles (LNPs) would be helpful but not essential. Must be willing and able to learn new technologies as needed.
  • Mass spectrometry experience useful but not essential.
  • Demonstrated track record of independent thinking, creativity, and scientific accomplishment.
  • Highly responsible and self-motivated. Skills to plan and conduct experiments with high quality and timely deliverables.
  • Team player with excellent collaboration and communication skills.

#LI-Onsite

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

  • The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
  • We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
  • This job is eligible to participate in our short-term incentive programs.

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.

AbbVie is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.

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Confirmed 2 hours ago. Posted 26 days ago.

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