Responsibilities include leading scientific research to identify, evaluate, and characterize relevant fluid biomarkers that will provide useful pharmacodynamic and efficacy endpoints in either preclinical or clinical settings. The successful candidate will be capable of multitasking, setting goals, priorities, and planning timelines. In addition, highly effective communication and collaboration are crucial.
• Develop strategy and scientific approach to identify novel diagnostic, prognostic, and pharmacodynamic biomarkers to enable scientific driven go/no go decisions for programs to assist in program progression
• Develop in vitro and biochemical assays to evaluate efficacy, PK/PD relationship, and novel biomarkers to characterize molecules for potential therapeutic effects
• Manage an associate scientist in the identification and validation of novel fluid biomarkers to enable scientific driven go/no go decisions for programs to assist in program progression
• Establish and manage external research collaborations to identify diagnostic and prognostic biomarkers of Parkinson’s Disease
• Participate in and lead cross-functional teams to support biomarker discovery and development
• Prepare, review and deliver high quality scientific presentations for internal/external use
• Develop strategies to identify and validate novel biomarkers to assist in program progression
• Learn new techniques and approaches as needed to tackle relevant questions
• Interact with various project teams as a liaison to share and distribute information
• Commitment to help the team achieve deliverables and meet aggressive timelines
External Posting Title
Scientist II, Translational Sciences
Research & Development
Basic experience in cellular and biochemical science such as standard molecular biology and protein biochemistry techniques (e.g. DNA cloning, protein purification, real-time PCR, Western blotting, immunoprecipitation, enzymatic assays) is required
--Strong track record in neuroscience, including experience working in Parkinson’s Disease fluid biomarkers is required
--Expertise in the cutting edge assay technologies and excellent assay troubleshooting skills
--Strong leadership skills and the ability to work independently or with minimal supervision in managing multiple projects and priorities
--Demonstrated track record of providing support activities for multiple research projects
--Solid work ethic and demonstrated record of productivity such as a contributing author on peer reviewed publications
--Experience in the development of biomarker assays in the preclinical and clinical setting
--Proven ability to deliver high quality drug candidates to first in human studies considered a plus
PhD in Neuroscience with at least 8 years post-PhD research experience including at least 3 years industry experience.
The Discovery and Early Development biomarker group, part of the Research and Early Development department is seeking an independent and highly motivated scientist to join a dynamic team engaged in the discovery and progression of novel biomarkers and therapeutics for neurodegenerative diseases.